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KMID : 0624620140470010039
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BMB Reports
2014 Volume.47 No. 1 p.39 ~ p.44
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miR-29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF-A
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Chen Ling
Xiao Hong
Wang Zong-Hua
Huang Yi
Liu Zi-Peng
Ren Hui
Song Hang
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Abstract
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Increasing data shows miR-29a is a key regulator of oncogenic processes. It is significantly down-regulated in some kind of human tumors and possibly functionally linked to cellular proliferation, survival and migration. However, the mechanism remains unclear. In this study, we report miR-29a is significantly under-expressed in gastric cancer compared to the healthy donor. The microvessel density is negatively related to miR-29a expression in gastric cancer tissues. The ectopic expression of miR-29a significantly inhibits proliferation and invasion of gastric cancer cells. Furthermore, western blot combined with the luciferase reporter assays demonstrate that vascular endothelial growth factor A (VEGF-A) is direct target of miR-29a. This is the first time miR-29a was found to suppress the tumor microvessel density in gastric cancer by targeting VEGF-A. Taken together, these results suggest that miR-29a is a tumor suppressor in gastric cancer. Restoration of miR-29a in gastric cancer may be a promising therapeutic approach.
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KEYWORD
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Gastric cancer, Hsa-miR-29a, MicroRNAs, Post-transcriptional regulation, VEGF-A
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